|
KMID : 0358320070480010072
|
|
Korean Journal of Urology
2007 Volume.48 No. 1 p.72 ~ p.76
|
|
|
Clinical Experience of 27 Pediatric Renal Transplantation at a Single Center
|
|
Kim Ki-Ho
Yae Suk-Jun
Kim Jae-Su
Kwon Tae-Gyun
Chung Sung-Kwang
|
|
|
Abstract
|
|
|
Purpose: Renal transplantation is considered the treatment of choice for children with end-stage renal disease(ESRD). The results of renal transplantation were retrospectively analyzed to assess certain aspects of pediatric renal transplantation.
Materials & Methods: Between January 1989 and January 2005, 27 pediatric kidney transplantations were carried out at our center. Fifteen (55.5%) patients underwent hemodialysis, two(7.4%) peritoneal dialysis and ten(37.0%) were conservative managed prior to treatment. Living- related donors provided 25(92.6%) of the transplanted organs, with cadaver sources utilized for 2(7.4%) patients. The donor age, organ source, etiology of ESRD, hospitalization period, postoperative complications, occurrence and number of acute rejections, and graft survival were assessed.
Results: The causes of renal failure were chronic glomerulonephritis in 10 patients[IgA 3 nephropathy, 3 membranoproliferative glomerulonephritis(MPGN), 2 nephrotic syndrome and 2 focal segmental glomerulosclerosis (FSGS)], urinary tract anomalies in 6(4 reflux nephropathy and 2 polycystic kidney), Alport syndrome in 1, hypertensive nephropathy in 2, systemic immunological disease in 1 and unknown causes in a further 5. Acute rejection occurred in 12 patients, all of who recovered after steroid pulse therapy. Growth and development failed in 2 patients. The postoperative complications included 4 urinary tract infections, 3 retroperitoneal hematomas, 2 lymphoceles and 1 acute ureteral obstruction. Four patients expired due to post-operative complications, such as disseminated intravascular coagulation(DIC), intracranial hematoma, sepsis and renal failure.
Conclusion: Pediatric renal transplantation can be successful, even in young children with ESRD.(Korean J Urol 2007;48:72-76)
|
|
|
KEYWORD
|
|
|
Kidney transplantation, Children
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|
|